AapCas12b Nuclease (10 μM) _ 14808ESThe AapCas12b nuclease (also known as C2c1) is a DNA endonuclease mediated by tracrRNA: crRNA (or sgRNA), derived from the thermophilic bacterium Alicyclobacillus acidophilus. In the presence of a PAM (TTN) sequence at the target double stranded DNA (dsDNA), it specifically cleaves the target dsDNA, causing double strand breaks and generating sticky ends. AapCas12b can specifically cleave single stranded DNA targets independent of the PAM sequence.

CD5 expression on developing thymocytes is positively regulated by signaling through the T cell antigen receptor (TCR) and is upregulated on tolerized peripheral CD4+ cells

adrenal gland

LZCap™AG(3'Ma-Cy7) is suitable for sequences starting with AG

Laminin 521 is a defined matrix for feeder-free culture of human embryonic (hES) and induced pluripotent (hiPS) stem  cells

Published 2021 Mar 23

This product can be compatible with Hifair™ V Reverse Transcriptase and various DNA polymerases verified by RT-PCR and RT-qPCR

Can nucleases from other brands also be tested

Cerulein can be used to study signal transduction pathways mediated by NF-κB up-regulated proteins such as intercellular adhesion molecule (ICAM-1)

FGF9 have been shown to improve systolic function after myocardial infarction in a clinical trial

a transmembrane region and a cytoplasmic tail with 4 immunoreceptor tyrosine-based inhibition motifs (ITIMs)

better reproducibility

This product should be stored at 2~8℃ away from light for 12 months